A role of glycation and methylation for SARS-CoV-2 infection in diabetes?
G Sartore, E Ragazzi, L Faccin, A Lapolla - Medical Hypotheses, 2020 - Elsevier
Abstract Type-2 diabetes (T2D) is a major comorbidity of COVID-19, and poorly controlled
diabetes is associated with high mortality rate, emphasizing the necessity to improve
glycemic control. Angiotensin-converting enzyme 2 (ACE2) is the receptor responsible for
SARS-CoV-2 access to human cells, and ACE2 expression is increased in patients with
diabetes and hypertension treated with ACE-inhibitors or angiotensin II receptor blockers.
We hypothesize that an upregulation of ACE2 due to its non-enzymatic glycation could be …
diabetes is associated with high mortality rate, emphasizing the necessity to improve
glycemic control. Angiotensin-converting enzyme 2 (ACE2) is the receptor responsible for
SARS-CoV-2 access to human cells, and ACE2 expression is increased in patients with
diabetes and hypertension treated with ACE-inhibitors or angiotensin II receptor blockers.
We hypothesize that an upregulation of ACE2 due to its non-enzymatic glycation could be …
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