A simple immune complex dissociation ELISA for leishmaniasis: standardization of the assay in experimental models and preliminary results in canine and human …
CA de Carvalho, AK Partata, RM Hiramoto… - Acta tropica, 2013 - Elsevier
Visceral leishmaniasis, caused by Leishmania (Leishmania) chagasi, is a chronic parasitic
disease of humans and dogs. Confirmation of the protozoal agent in bone marrow, lymph
node or spleen aspirate is diagnostic, while specific-IgG serology is used mainly for
epidemiology despite the general presence of high levels of serum immunoglobulin.
Anecdotal reports of false-negative serology in active disease cases are known and are
ascribed to the formation of immune complexes. Because dissociation of immune complexes …
disease of humans and dogs. Confirmation of the protozoal agent in bone marrow, lymph
node or spleen aspirate is diagnostic, while specific-IgG serology is used mainly for
epidemiology despite the general presence of high levels of serum immunoglobulin.
Anecdotal reports of false-negative serology in active disease cases are known and are
ascribed to the formation of immune complexes. Because dissociation of immune complexes …
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