A simple strategy for breakpoint fragment determination in chronic myeloid leukemia
AM Kamel, HM Shaker, FH GadAllah… - Cancer Genetics and …, 2000 - Elsevier
Molecular characterization is considered a part of the routine work-up of chronic myeloid
leukemia (CML) cases. Southern blot analysis using the universal BCR (UBCR) probe on
BglII-digested DNA samples is the most commonly used technique, while employing the
human 3′ bcr probe (PR-1) is usually considered a complementary tool. In this study, we
tried to develop a simple and economic strategy for molecular characterization of CML using
the 3′ probe as it has been shown to be the one capable of locating the breakpoint site …
leukemia (CML) cases. Southern blot analysis using the universal BCR (UBCR) probe on
BglII-digested DNA samples is the most commonly used technique, while employing the
human 3′ bcr probe (PR-1) is usually considered a complementary tool. In this study, we
tried to develop a simple and economic strategy for molecular characterization of CML using
the 3′ probe as it has been shown to be the one capable of locating the breakpoint site …
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