A single salt bridge in VIM-20 increases protein stability and antibiotic resistance under low-zinc conditions
Z Cheng, BA Shurina, CR Bethel, PW Thomas… - Mbio, 2019 - Am Soc Microbiol
To understand the evolution of Verona integron-encoded metallo-β-lactamase (VIM) genes
(bla VIM) and their clinical impact, microbiological, biochemical, and structural studies were
conducted. Forty-five clinically derived VIM variants engineered in a uniform background
and expressed in Escherichia coli afforded increased resistance toward all tested antibiotics;
the variants belonging to the VIM-1-like and VIM-4-like families exhibited higher MICs
toward five out of six antibiotics than did variants belonging to the widely distributed and …
(bla VIM) and their clinical impact, microbiological, biochemical, and structural studies were
conducted. Forty-five clinically derived VIM variants engineered in a uniform background
and expressed in Escherichia coli afforded increased resistance toward all tested antibiotics;
the variants belonging to the VIM-1-like and VIM-4-like families exhibited higher MICs
toward five out of six antibiotics than did variants belonging to the widely distributed and …
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