A stake in the game: ADAM23 contributes to dendritic cell effectiveness in stimulating CD4+ T cell proliferative responses
J Cabral, MD Griffin - Journal of Leucocyte Biology, 2016 - academic.oup.com
J Cabral, MD Griffin
Journal of Leucocyte Biology, 2016•academic.oup.com… -generated DCs suggest that ADAM23/αV/β3 integrin interactions exert a positive effect on
early signaling events involved in primary, antigen-specific activation of resting CD4 + T cells in
mouse—perhaps participating in the formation and effective function of the IS—without overtly
skewing the eventual T cell effector phenotype. It … In essence, this study has identified, for the
first time, that ADAM23 is a potentially important DC receptor that may play a unique role in
supporting effective, antigen-specific T cell activation. As there is a well-recognized need to …
early signaling events involved in primary, antigen-specific activation of resting CD4 + T cells in
mouse—perhaps participating in the formation and effective function of the IS—without overtly
skewing the eventual T cell effector phenotype. It … In essence, this study has identified, for the
first time, that ADAM23 is a potentially important DC receptor that may play a unique role in
supporting effective, antigen-specific T cell activation. As there is a well-recognized need to …
Abstract
Discussion on how ADAM23 is expressed by some DCs in mice and provides a positive co-stimulus during antigen-specific activation of CD4+ T cells.
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