A subset of so‐called dermal non‐neural granular cell tumours are underlined by ALK fusions, further supporting the idea that they represent a variant of epithelioid …
RE Perret, ML Jullie, B Vergier, JM Coindre… - …, 2018 - search.ebscohost.com
RE Perret, ML Jullie, B Vergier, JM Coindre, F Le Loarer
Histopathology, 2018•search.ebscohost.comThe article presents a study in which two cases were investigated that showed features
consistent with non-neural granular cell tumours (NN-GCT) by immunohistochemistry and
fluorescence in-situ hybridisation, on the basis that ALK rearrangements and
overexpression have been recently demonstrated in epithelioid fibrous histiocytoma (EFH). It
states that tumours showed ample granular eosinophilic cytoplasm, variably prominent
nucleoli, mild atypia, and were negative for neural markers.
consistent with non-neural granular cell tumours (NN-GCT) by immunohistochemistry and
fluorescence in-situ hybridisation, on the basis that ALK rearrangements and
overexpression have been recently demonstrated in epithelioid fibrous histiocytoma (EFH). It
states that tumours showed ample granular eosinophilic cytoplasm, variably prominent
nucleoli, mild atypia, and were negative for neural markers.
Abstract
The article presents a study in which two cases were investigated that showed features consistent with non-neural granular cell tumours (NN-GCT) by immunohistochemistry and fluorescence in-situ hybridisation, on the basis that ALK rearrangements and overexpression have been recently demonstrated in epithelioid fibrous histiocytoma (EFH). It states that tumours showed ample granular eosinophilic cytoplasm, variably prominent nucleoli, mild atypia, and were negative for neural markers.
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