Water shortage and stress around the world lead to the reuse of wastewater in many sectors while the recycling of water in agriculture as one of the most consumed sectors can boost the contamination of crops by potentially toxic elements (PTEs). Therefore, this study was aimed to investigate the correlation between the accumulation of PTEs (Fe, Zn, Cr, Ni, Cu, Pb, As, Cd, and Se) in edible parts of spinach and radish plants and sewage irrigation by the aid of a meta-analysis. Moreover, the non-carcinogenic risk (N-CR) and carcinogenic risk (CR) for health risk assessment of consumers were assessed through actual total target hazard quotient (TTHQact) and carcinogenic risk (CRact). After the screening process, 51 articles with 75 studies were included. According to findings, the rank order of PTEs in spinach and radish were Fe > Zn > Cr > Cu > Ni > Pb > Cd > As > Se and Fe > Zn > Cr > Ni > Cu > Pb > As > Cd > Se, respectively. PTE adsorption by edible parts of spinach (leafy vegetable) was higher than radish. The health risk assessment shows that residents in Iran, India, and China are at N-CR while the population of Iran, India, and Pakistan are facing CR.