A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases …
H Wesseling, H Rahmoune, M Tricklebank… - Journal of Proteome …, 2015 - ACS Publications
There is substantial interest in the N-methyl-d-aspartate (NMDA) receptor antagonist
ketamine in psychiatric research because it exerts acute psychotomimetic and rapid
antidepressant effects in rodents and humans. Here, we investigated proteomic changes in
brain and serum after acute treatment of rats with ketamine using two targeted proteomic
profiling methods. Multiplex immunoassay profiling of serum identified altered levels of
interleukin 4, tumor necrosis factor alpha, and fibroblast growth factor 9, suggesting a link …
ketamine in psychiatric research because it exerts acute psychotomimetic and rapid
antidepressant effects in rodents and humans. Here, we investigated proteomic changes in
brain and serum after acute treatment of rats with ketamine using two targeted proteomic
profiling methods. Multiplex immunoassay profiling of serum identified altered levels of
interleukin 4, tumor necrosis factor alpha, and fibroblast growth factor 9, suggesting a link …
[引用][C] A Targeted Multiplexed Proteomic Investigation Identifies Ketamine-Induced Changes in Immune Markers in Rat Serum and Expression Changes in Protein …
W Hendrik, R Hassan, T Mark, B Sabine - 2015
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