Experimental observations performed in the p53-Mdm2 network, one of the key protein
modules involved in the control of proliferation of abnormal cells in mammals, revealed the
existence of two frequencies of oscillations of p53 and Mdm2 in irradiated cells depending
on the irradiation dose. These observations raised the question of the existence of
birhythmicity, ie the coexistence of two oscillatory regimes for the same external conditions,
in the p53-Mdm2 network which would be at the origin of these two distinct frequencies. A …

Experimental observations performed in the p53-Mdm2 network, one of the key protein
module involved in the control of proliferation of abnormal cells in mammals, revealed the
existence of two frequencies of oscillations of p53 and Mdm2 in irradiated cells depending
on the irradiation dose. Recently, Ouattara, Abou-Jaoudé and Kaufman proposed a 3-
dimensional differential model showing birhythmicity, ie the coexistence between two stable
oscillatory regimes for the same external conditions, to reproduce the two frequencies …