A Unimolecular G-Quadruplex that Functions as a Synthetic Transmembrane Na+ Transporter
MS Kaucher, WA Harrell, JT Davis - Journal of the American …, 2006 - ACS Publications
MS Kaucher, WA Harrell, JT Davis
Journal of the American Chemical Society, 2006•ACS PublicationsWe describe the covalent post-modification of a hydrogen-bonded assembly with the
subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is
used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting
unimolecular G-quadruplex folds in the environment of a phospholipid membrane and
functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport
assays.
subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is
used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting
unimolecular G-quadruplex folds in the environment of a phospholipid membrane and
functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport
assays.
We describe the covalent post-modification of a hydrogen-bonded assembly with the subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting unimolecular G-quadruplex folds in the environment of a phospholipid membrane and functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport assays.
ACS Publications以上显示的是最相近的搜索结果。 查看全部搜索结果