A Unique Modification of the Eukaryotic Initiation Factor 5A Shows the Presence of the Complete Hypusine Pathway in Leishmania donovani
B Chawla, RR Kumar, N Tyagi, G Subramanian… - PloS one, 2012 - journals.plos.org
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational
synthesis of an unusual amino acid hypusine (N€-(4-amino-2-hydroxybutyl) lysine), which is
present on only one cellular protein, eukaryotic initiation factor 5A (eIF5A). We present here
the molecular and structural basis of the function of DOHH from the protozoan parasite,
Leishmania donovani, which causes visceral leishmaniasis. The L. donovani DOHH gene is
981 bp and encodes a putative polypeptide of 326 amino acids. DOHH is a HEAT-repeat …
synthesis of an unusual amino acid hypusine (N€-(4-amino-2-hydroxybutyl) lysine), which is
present on only one cellular protein, eukaryotic initiation factor 5A (eIF5A). We present here
the molecular and structural basis of the function of DOHH from the protozoan parasite,
Leishmania donovani, which causes visceral leishmaniasis. The L. donovani DOHH gene is
981 bp and encodes a putative polypeptide of 326 amino acids. DOHH is a HEAT-repeat …
A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.
BC Bhavna Chawla, RR Kumar, NT Nidhi Tyagi… - 2012 - cabidigitallibrary.org
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational
synthesis of an unusual amino acid hypusine (N 6-(4-amino-2-hydroxybutyl) lysine), which is
present on only one cellular protein, eukaryotic initiation factor 5A (eIF5A). We present here
the molecular and structural basis of the function of DOHH from the protozoan parasite,
Leishmania donovani, which causes visceral leishmaniasis. The L. donovani DOHH gene is
981 bp and encodes a putative polypeptide of 326 amino acids. DOHH is a HEAT-repeat …
synthesis of an unusual amino acid hypusine (N 6-(4-amino-2-hydroxybutyl) lysine), which is
present on only one cellular protein, eukaryotic initiation factor 5A (eIF5A). We present here
the molecular and structural basis of the function of DOHH from the protozoan parasite,
Leishmania donovani, which causes visceral leishmaniasis. The L. donovani DOHH gene is
981 bp and encodes a putative polypeptide of 326 amino acids. DOHH is a HEAT-repeat …
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