AB0781 ASSOCIATION OF MICA POLYMORPHISM AND SERUM LEVELS WITH PREDISPOSITION TO PSORIATIC ARTHRITIS
R Sokolik, M Dratwa, J Wielinska, M Iwaszko… - 2019 - ard.bmj.com
R Sokolik, M Dratwa, J Wielinska, M Iwaszko, M Chaszczewska-Markowska, P Wiland…
2019•ard.bmj.comBackground: Psoriatic arthritis (PsA) is a multifactorial chronic inflammatory disease
manifested by joint inflammation and cutaneous psoriasis. The precise etiology of PsA
remains unknown, however both genetic and environmental factors contribute to
development of this immune-mediated disease. Objectives: This present study aimed to
assess whether polymorphism within gene coding for major histocompatibility complex
(MHC) class I chain-related a (MICA) proteins could be a prognostic factor of PsA. Methods …
manifested by joint inflammation and cutaneous psoriasis. The precise etiology of PsA
remains unknown, however both genetic and environmental factors contribute to
development of this immune-mediated disease. Objectives: This present study aimed to
assess whether polymorphism within gene coding for major histocompatibility complex
(MHC) class I chain-related a (MICA) proteins could be a prognostic factor of PsA. Methods …
Background
Psoriatic arthritis (PsA) is a multifactorial chronic inflammatory disease manifested by joint inflammation and cutaneous psoriasis. The precise etiology of PsA remains unknown, however both genetic and environmental factors contribute to development of this immune-mediated disease.
Objectives
This present study aimed to assess whether polymorphism within gene coding for major histocompatibility complex (MHC) class I chain-related a (MICA) proteins could be a prognostic factor of PsA.
Methods
For this purpose 77 PsA patients and 234 controls were enrolled to the study on MICA polymorphic variants. Genotyping for MICA rs1051792 (Met/Val; G>A) was performed using a LightSNiP assay. In addition the MICA serum levels were studied in 66 patients and 99 controls employing Luminex assay.
Results
Interestingly, MICA polymorphism was found to affect the susceptibility to PsA. The presence of the a (Val) variant was found to increase the risk of PsA (OR= 1.932, p=0.022).
No significant differences were detected between MICA serum levels in patients and controls. However, patients carrying this risk variant (A allele) characterized with lower MICA serum levels as compared GG homozygotes (p=0.018)
Conclusion
These results imply that MICA polymorphism may constitute a risk factor of PsA and be associated with MICA serum levels in PsA patients.
Supported by the National Science Centre (Poland) grant: 2016/21/B/NZ5/01901.
Disclosure of interests
None declared
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