Smart E-Learning is an education form, in which information technology plays an important role. Smart E-Learning utilizes the achievements of modern technologies such as artificial intelligence (AI). So, it can help to gain the ability of connectivity, sharing, convenience, and flexibility for learners. All activities including teaching, learning, discussing, testing, and grading, are well done over the internet environment. However, some potential risks can cause participants, especially, about data privacy. The issue is a big challenge for developing applications for smart E-Learning. Therefore, the goal to combine E-Learning with Blockchain technology to improve security for smart E-Learning is necessary. In this paper, we discuss potential and challenge for applying AI and Blockchain for developing applications for smart E-Learning in Vietnam. We also propose to combine independent testing models integrated with AI and Blockchain into the same smart E-Learning system.