APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
Oral squamous cell carcinoma is a prominent cancer worldwide, particularly in Taiwan. By
integrating omics analyses in 50 matched samples, we uncover in Taiwanese patients a
predominant mutation signature associated with cytidine deaminase APOBEC, which
correlates with the upregulation of APOBEC3A expression in the APOBEC3 gene cluster at
22q13. APOBEC3A expression is significantly higher in tumors carrying APOBEC3B-
deletion allele (s). High-level APOBEC3A expression is associated with better overall …
integrating omics analyses in 50 matched samples, we uncover in Taiwanese patients a
predominant mutation signature associated with cytidine deaminase APOBEC, which
correlates with the upregulation of APOBEC3A expression in the APOBEC3 gene cluster at
22q13. APOBEC3A expression is significantly higher in tumors carrying APOBEC3B-
deletion allele (s). High-level APOBEC3A expression is associated with better overall …
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