Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis
OBJECTIVES: Psoriasis is a Th-1/17 mediated inflammatory disease associated with
increased risk of cardiovascular disease (CVD). Inflammation may modulate lipoprotein
particle number and directly impair HDL functions, in particular reverse cholesterol transport
(RCT). We sought to study how chronic in vivo inflammation modulates lipoprotein particle
composition using nuclear magnetic resonance spectroscopy (NMR) and HDL efflux in
psoriasis. METHODS AND RESULTS: We prospectively enrolled a consecutive sample of …
increased risk of cardiovascular disease (CVD). Inflammation may modulate lipoprotein
particle number and directly impair HDL functions, in particular reverse cholesterol transport
(RCT). We sought to study how chronic in vivo inflammation modulates lipoprotein particle
composition using nuclear magnetic resonance spectroscopy (NMR) and HDL efflux in
psoriasis. METHODS AND RESULTS: We prospectively enrolled a consecutive sample of …
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