Accelerated blood clearance phenomenon reduces the passive targeting of PEGylated nanoparticles in peripheral arterial disease
Peripheral arterial disease (PAD) is a leading global health concern. Due to limited imaging
and therapeutic options, PAD and other ischemia-related diseases may benefit from the use
of long circulating nanoparticles as imaging probes and/or drug delivery vehicles.
Polyethylene glycol (PEG)-conjugated nanoparticles have shown shortened circulation half-
lives in vivo when injected multiple times into a single subject. This phenomenon has
become known as the accelerated blood clearance (ABC) effect. The phenomenon is of …
and therapeutic options, PAD and other ischemia-related diseases may benefit from the use
of long circulating nanoparticles as imaging probes and/or drug delivery vehicles.
Polyethylene glycol (PEG)-conjugated nanoparticles have shown shortened circulation half-
lives in vivo when injected multiple times into a single subject. This phenomenon has
become known as the accelerated blood clearance (ABC) effect. The phenomenon is of …
[引用][C] Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease
I Hyung-Jun, F Liangzhu, H Reinier, L Zhuang, LD Soo… - 2016
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