Female Fischer 344 rats were exposed to three MOSH mixtures: oils largely below and
above C 25 (S-C25 and L-C25) and a 1: 1 mixture of L-C25 with a wax; doses of 400, 1000
and 4000 mg/kg feed were administered during 120 days. MOSH were determined by on-
line HPLC-GC-FID in liver, spleen, adipose tissue and the carcass. The composition of the
hydrocarbons accumulated in the tissues was further analyzed by comprehensive two-
dimensional GC (GC× GC). MOSH in the mass range of C 26–30 were more strongly …

Female Fischer 344 rats were orally exposed to a mixture of mineral oil saturated
hydrocarbons (MOSH) of broad molecular mass range at doses of 40, 400 and 4000 mg/kg
feed. Amounts and compositions of the MOSH were analyzed in liver, spleen, adipose tissue
and the carcass after exposure during 30, 60, 90 and 120 d as well as after 90 d exposure
followed by 30 d depuration. At 40 mg/kg in the feed, after 30 d of exposure, 10.9% of the
ingested MOSH were recovered from the animal body; after 90 d plus 30 d depuration it was …