Acetylation of cAMP-responsive element-binding protein (CREB) by CREB-binding protein enhances CREB-dependent transcription
Q Lu, AE Hutchins, CM Doyle, JR Lundblad… - Journal of Biological …, 2003 - ASBMB
The coactivator function of cAMP-responsive element-binding protein (CREB)-binding
protein (CBP) is partly caused by its histone acetyltransferase activity. However, it has
become increasingly clear that CBP acetylates both histones and non-histone proteins,
many of which are transcription factors. Here we investigate the role of CBP acetylase
activity in CREB-mediated gene expression. We show that CREB is acetylated within the cell
and that in vitro, CREB is acetylated by CBP, but not by another acetylase, p300/CBP …
protein (CBP) is partly caused by its histone acetyltransferase activity. However, it has
become increasingly clear that CBP acetylates both histones and non-histone proteins,
many of which are transcription factors. Here we investigate the role of CBP acetylase
activity in CREB-mediated gene expression. We show that CREB is acetylated within the cell
and that in vitro, CREB is acetylated by CBP, but not by another acetylase, p300/CBP …