Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc
F Bock, K Shahzad, H Wang… - Proceedings of the …, 2013 - National Acad Sciences
The coagulation protease activated protein C (aPC) confers cytoprotective effects in various
in vitro and in vivo disease models, including diabetic nephropathy. The nephroprotective
effect may be related to antioxidant effects of aPC. However, the mechanism through which
aPC may convey these antioxidant effects and the functional relevance of these properties
remain unknown. Here, we show that endogenous and exogenous aPC prevents glomerular
accumulation of oxidative stress markers and of the redox-regulating protein p66Shc in …
in vitro and in vivo disease models, including diabetic nephropathy. The nephroprotective
effect may be related to antioxidant effects of aPC. However, the mechanism through which
aPC may convey these antioxidant effects and the functional relevance of these properties
remain unknown. Here, we show that endogenous and exogenous aPC prevents glomerular
accumulation of oxidative stress markers and of the redox-regulating protein p66Shc in …
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