PI3K/Akt/mTOR activation by suppression of ELK3 mediates chemosensitivity of MDA-MB-231 cells to doxorubicin by inhibiting autophagy

JH Park, KP Kim, JJ Ko, KS Park - Biochemical and biophysical research …, 2016 - Elsevier
… In this study, we show that suppression of ELK3 induces sensitivity of MDA-MB-231 cells
to doxorubicin treatment. Impairment of autophagy in ELK3-knockdown MDA-MB-231 cells (…

Giant suppression of the activation rate in the presence of correlated white noise sources

AJR Madureira, P Hänggi, HS Wio - Physics Letters A, 1996 - Elsevier
… For decreasing values of intensity of the additive noise D, the suppression of the reaction
rate becomes more drastic. We also plot the steepest descent approximation of the relative …

Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung …

Y Masuda, Y Murata, M Hayashi… - Biological and …, 2008 - jstage.jst.go.jp
… This study therefore investigated whether the inhibitory effect of MD-Fraction on lung
metastasis was due to activation of NK cells and suppression of adhesion molecule expression in …

Matrix-specific suppression of integrin activation in shear stress signaling

AW Orr, MH Ginsberg, SJ Shattil… - Molecular biology of …, 2006 - Am Soc Cell Biol
… However, because new ligation of α2β1 is required for suppression of αvβ3 and α5β1, we
also assayed whether inhibition of PKA altered the ability of flow to stimulate activation of α2β1 …

… transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of …

AB Kunnumakkara, AS Nair, KS Ahn… - … , The Journal of the …, 2007 - ashpublications.org
… gossypin mediates its effects through modulation of NF-κB activation. In the present study, …
activation induced by inflammatory stimuli and carcinogens. Constitutive NF-κB activation in …

Di (2‐ethylhexyl) phthalate‐induced apoptosis in rat INS‐1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection

X Sun, Y Lin, Q Huang, J Shi, L Qiu… - Journal of cellular …, 2015 - Wiley Online Library
… suggested that DEHP-mediated activation of PERK demonstrated no obvious effect on the
nuclear translocation of Nrf2 and the subsequent induction of target genes induction in INS-1 …

… of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated …

T Yoshimura, A Takeda, S Hamano… - The Journal of …, 2006 - journals.aai.org
… for the suppression ofof various proinflammatory cytokines by fully activated CD4 + T cells
while it had no effect on the cytokine production by CD4 + T cells at early phases of activation. …

[HTML][HTML] VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore

M Okazaki, K Kurabayashi, M Asanuma, Y Saito… - … et Biophysica Acta (BBA …, 2015 - Elsevier
… We found that channel gating of VDAC3 was activated by suppression of disulfide-bond
formation, becoming similar to that of VDAC1 and VDAC2. Several proteins are known to form …

Activation or suppression of the tumoricidal properties of monocytes from cancer patients following treatment with human recombinant γ-interferon

ES Kleinerman, R Kurzrock, D Wyatt, JR Quesada… - Cancer research, 1986 - AACR
of appropriate amounts of IFN-7 can activate blood monocytes of cancer patients to become
… the activation of tumoricidal prop erties in blood monocytes of normal donors (22) or …

… mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation

YJ Surh, KS Chun, HH Cha, SS Han, YS Keum… - … Mechanisms of …, 2001 - Elsevier
… COX-2 activity since they did not influence the catalytic activity of the enzyme when added
… pre-treatment of PDTC resulted in dose-related suppression of TPA-induced activation of NF-…