Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo
D Liu, J Su, J Lin, G Qian, X Chen, S Song… - International journal of …, 2018 - Elsevier
Recent studies have highlighted the immune stress caused by ochratoxin A (OTA), but little
attention was paid to its alleviation. In the present study, the protective effects of astragalus
polysaccharide (APS) against OTA-induced immune stress in vitro and in vivo and its
mechanism/(s) involved were investigated. The in vitro results showed that APS (20 μg/ml)
induced a significant decrease in cytotoxicity, apoptosis and pro-inflammatory cytokine
expressions elevated by OTA (1.5 μg/ml) in porcine alveolar macrophages (PAMs). In vivo …
attention was paid to its alleviation. In the present study, the protective effects of astragalus
polysaccharide (APS) against OTA-induced immune stress in vitro and in vivo and its
mechanism/(s) involved were investigated. The in vitro results showed that APS (20 μg/ml)
induced a significant decrease in cytotoxicity, apoptosis and pro-inflammatory cytokine
expressions elevated by OTA (1.5 μg/ml) in porcine alveolar macrophages (PAMs). In vivo …
Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo.
LDD Liu DanDan, SJR Su JiaRui, LJS Lin JiaShan… - 2018 - cabidigitallibrary.org
Recent studies have highlighted the immune stress caused by ochratoxin A (OTA), but little
attention was paid to its alleviation. In the present study, the protective effects of astragalus
polysaccharide (APS) against OTA-induced immune stress in vitro and in vivo and its
mechanism/(s) involved were investigated. The in vitro results showed that APS (20 µg/ml)
induced a significant decrease in cytotoxicity, apoptosis and pro-inflammatory cytokine
expressions elevated by OTA (1.5 µg/ml) in porcine alveolar macrophages (PAMs). In vivo …
attention was paid to its alleviation. In the present study, the protective effects of astragalus
polysaccharide (APS) against OTA-induced immune stress in vitro and in vivo and its
mechanism/(s) involved were investigated. The in vitro results showed that APS (20 µg/ml)
induced a significant decrease in cytotoxicity, apoptosis and pro-inflammatory cytokine
expressions elevated by OTA (1.5 µg/ml) in porcine alveolar macrophages (PAMs). In vivo …