Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity
Mucosal-associated invariant T (MAIT) cells can be activated by viruses through a cytokine-
dependent mechanism, and thereby protect from lethal infection. Given this, we reasoned
MAIT cells may have a critical role in the immunogenicity of replication-incompetent
adenovirus vectors, which are novel and highly potent vaccine platforms. In vitro, ChAdOx1
(Chimpanzee Adenovirus Ox1) induced potent activation of MAIT cells. Activation required
transduction of monocytes and plasmacytoid dendritic cells to produce IL-18 and IFN-α …
dependent mechanism, and thereby protect from lethal infection. Given this, we reasoned
MAIT cells may have a critical role in the immunogenicity of replication-incompetent
adenovirus vectors, which are novel and highly potent vaccine platforms. In vitro, ChAdOx1
(Chimpanzee Adenovirus Ox1) induced potent activation of MAIT cells. Activation required
transduction of monocytes and plasmacytoid dendritic cells to produce IL-18 and IFN-α …
以上显示的是最相近的搜索结果。 查看全部搜索结果