[HTML][HTML] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood
and is refractory to current targeted therapies. Using a genetic screen, we identify the
PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently
suppresses mammary epithelial cell proliferation and transformation. PTPN12 is frequently
compromised in human TNBCs, and we identify an upstream tumor-suppressor network that
posttranscriptionally controls PTPN12. PTPN12 suppresses transformation by interacting …
and is refractory to current targeted therapies. Using a genetic screen, we identify the
PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently
suppresses mammary epithelial cell proliferation and transformation. PTPN12 is frequently
compromised in human TNBCs, and we identify an upstream tumor-suppressor network that
posttranscriptionally controls PTPN12. PTPN12 suppresses transformation by interacting …
[PDF][PDF] Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase
S Tingting, N Aceto, KL Meerbrey… - … журнал МОЗ України, 2012 - irbis-nbuv.gov.ua
Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood
and is refractory to current targeted therapies. Using a genetic screen, we identify the
PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently
suppresses mammary epithelial cell proliferation and transformation. PTPN12 is frequently
compromised in human TNBCs, and we identify an upstream tumor-suppressor network that
posttranscriptionally controls PTPN12. PTPN12 suppresses transforma-tion by interacting …
and is refractory to current targeted therapies. Using a genetic screen, we identify the
PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently
suppresses mammary epithelial cell proliferation and transformation. PTPN12 is frequently
compromised in human TNBCs, and we identify an upstream tumor-suppressor network that
posttranscriptionally controls PTPN12. PTPN12 suppresses transforma-tion by interacting …
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