Apoptosis was induced in human glioma cell lines by exposure to 100 nm calphostin C, a
specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with
synchronous down-regulation of Bcl-2 and Bcl-x L as well as activation of caspase-3 but not
caspase-1. The exposure to calphostin C led to activation of stress-activated protein kinase/c-
Jun NH 2-terminal kinase (SAPK/JNK) and p38 kinase and concurrent inhibition of
extracellular signal-regulated kinase (ERK). Upstream of ERK, Shc was shown to be …

CiNii 博士論文 - Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and
p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is
dispensable for cell death … Activation of stress-activated protein kinase/c-Jun NH2-terminal
kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like
proteases but is dispensable for cell death カルホスチンC誘導アポトーシスにおけるSAPK/JNK及び
p38の活性化はカスペース-3様プロテアーゼを必要とするが細胞死には関与しない … カルホスチン …