Cells are continuously exposed to damaging reactive oxygen species (ROS), which are
produced from both endogenous and exogenous sources. 8-Oxodeoxyguanosine (8-oxodG)
is an abundant base lesion formed during oxidative stress which, if not repaired, can give
rise to G: C→ T: A transversions in DNA. The 8-oxoguanine DNA glycosylase-1 (OGG1)-
initiated base excision repair (BER) pathway operates to remove 8-oxodG lesions. Ogg1
deletion and polymorphism may result in a hypermutator phenotype and susceptibility to …