Acute chest syndrome in adults with sickle cell disease
Study objectives Acute chest syndrome (ACS) is a frequent and potentially severe
pulmonary illness in sickle cell disease (SCD). The aim of the study was to report the clinical
features and outcome of consecutive ACS episodes in adult patients in a French SCD
center. All patients were treated according to an uniform therapeutic protocol applying
transfusion only in the more severe clinical form of ACS. Results There were 107
consecutive episodes in 77 adult patients (mean age, 29±7 years; 78% hemoglobin [Hb] SS; …
pulmonary illness in sickle cell disease (SCD). The aim of the study was to report the clinical
features and outcome of consecutive ACS episodes in adult patients in a French SCD
center. All patients were treated according to an uniform therapeutic protocol applying
transfusion only in the more severe clinical form of ACS. Results There were 107
consecutive episodes in 77 adult patients (mean age, 29±7 years; 78% hemoglobin [Hb] SS; …
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