Acute elevation of triglycerides after initiation of fosamprinavir/ritonavir in an HIV-negative patient with baseline hypertriglyceridemia
It is well established that protease inhibitors (PI) can contribute to development of insulin
resistance, diabetes mellitus (DM), and hyperlipidemia (in particular, hypertriglyceridemia
[HTG]) compared to other antiretrovirals. 1 Several studies have documented triglyceride
(TG) elevations of variable magnitude after short-term use of PI in healthy human
immunodeficiency virus (HIV)-negative adult patients with normal TG at baseline. These
reports include elevations in TG of 6% after 5 days of nonritonavirboosted atazanavir (ATV) …
resistance, diabetes mellitus (DM), and hyperlipidemia (in particular, hypertriglyceridemia
[HTG]) compared to other antiretrovirals. 1 Several studies have documented triglyceride
(TG) elevations of variable magnitude after short-term use of PI in healthy human
immunodeficiency virus (HIV)-negative adult patients with normal TG at baseline. These
reports include elevations in TG of 6% after 5 days of nonritonavirboosted atazanavir (ATV) …
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