Acute toxicity screening of novel AChE inhibitors using neuronal networks on microelectrode arrays
EW Keefer, SJ Norton, NAJ Boyle, V Talesa, GW Gross - Neurotoxicology, 2001 - Elsevier
Spontaneously active neuronal networks grown from embryonic murine frontal cortex on
substrate integrated electrode arrays with 64 recording sites were used to assess acute
neurobiological and toxic effects of a series of seven symmetrical, bifunctional alkylene-
linked bis-thiocarbonate compounds designed to possess anticholinesterase activity. Acute
functional neurotoxicity in the absence of cytotoxicity was defined as total collapse of
spontaneous activity. All of the compounds were characterized as mixed inhibitors of AChE …
substrate integrated electrode arrays with 64 recording sites were used to assess acute
neurobiological and toxic effects of a series of seven symmetrical, bifunctional alkylene-
linked bis-thiocarbonate compounds designed to possess anticholinesterase activity. Acute
functional neurotoxicity in the absence of cytotoxicity was defined as total collapse of
spontaneous activity. All of the compounds were characterized as mixed inhibitors of AChE …
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