Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function
TJ Grevengoed, SA Martin, L Katunga, DE Cooper… - Journal of lipid …, 2015 - ASBMB
Long-chain acyl-CoA synthetase 1 (ACSL1) contributes more than 90% of total cardiac
ACSL activity, but its role in phospholipid synthesis has not been determined. Mice with an
inducible knockout of ACSL1 (Acsl1 T−/−) have impaired cardiac fatty acid oxidation and rely
on glucose for ATP production. Because ACSL1 exhibited a strong substrate preference for
linoleate, we investigated the composition of heart phospholipids. Acsl1 T−/− hearts
contained 83% less tetralinoleoyl-cardiolipin (CL), the major form present in control hearts. A …
ACSL activity, but its role in phospholipid synthesis has not been determined. Mice with an
inducible knockout of ACSL1 (Acsl1 T−/−) have impaired cardiac fatty acid oxidation and rely
on glucose for ATP production. Because ACSL1 exhibited a strong substrate preference for
linoleate, we investigated the composition of heart phospholipids. Acsl1 T−/− hearts
contained 83% less tetralinoleoyl-cardiolipin (CL), the major form present in control hearts. A …
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