Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission
Drp1 (dynamin-related protein 1) is recruited to both mitochondrial and peroxisomal
membranes to execute fission. Fis1 and Mff are Drp1 receptor/effector proteins of
mitochondria and peroxisomes. Recently, MiD49 and MiD51 were also shown to recruit
Drp1 to the mitochondrial surface; however, different reports have ascribed opposing roles
in fission and fusion. Here, we show that MiD49 or MiD51 overexpression blocked fission by
acting in a dominant-negative manner by sequestering Drp1 specifically at mitochondria …
membranes to execute fission. Fis1 and Mff are Drp1 receptor/effector proteins of
mitochondria and peroxisomes. Recently, MiD49 and MiD51 were also shown to recruit
Drp1 to the mitochondrial surface; however, different reports have ascribed opposing roles
in fission and fusion. Here, we show that MiD49 or MiD51 overexpression blocked fission by
acting in a dominant-negative manner by sequestering Drp1 specifically at mitochondria …
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