The extracellular matrix (ECM) of adipose tissues undergoes constant remodelling to allow
adipocytes and their precursor cells to change cell shape and function in adaptation to
nutritional cues. Abnormal accumulation of ECM components and their modifiers in adipose
tissues has been recently demonstrated to cause obesity-associated insulin resistance, a
hallmark of type 2 diabetes. Integrins and other ECM receptors (eg CD44) that are
expressed in adipose tissues have been shown to regulate insulin sensitivity. It is well …

Obesity drives an excessive triglycerides accumulation in adipose tissue, which incites
immune cell infiltration, causing fibrosis and inflammation, causing local hypoxia in
adipocytes, and ultimately insulin resistance. The extracellular matrix (ECM) complex
network of proteins and proteoglycans that offer a scaffold for cells controlling differentiation,
migration, repair, survival, and development, and ECM remodeling is required for healthy
adipose tissue expansion. To understand the molecular mechanism of this process is a …