… organs, there have been few reports concerning stem cells in the heart. We here demonstrate
that Sca-1-positive (Sca-1+) cells in adult hearts have some of the features of stem cells. …

… In addition, Sca-1 − Spoc cells can also differentiate into beating cardiomyocytes in vitro [9]. …
cardiac differentiation in vitro. The percentage of cells differentiating into cardiomyocytes …

… , in the adult, of cardiomyocyte turnover events and of cardiac … The heart tube starts beating
at around embryonic day (E)8.0 [68]… mouse lung are highly enriched in the Sca-1 positive cell …

… However, the cellular origin of cardiomyocyte renewal has … focusing on putative adult
cardiac precursor cells. We have … cardiomyocytes originated from differentiating Sca1-positive …

… /progenitor cells have the ability to differentiate into all cell … mature beating cardiomyocytes
invariably in all the purified … Sca-1 + cells expressed mature cardiomyocyte gene markers …

… cells was first described in 2002 in CSCs from mouse heart [2]. … differentiation into a variety
cells such as cardiomyocytes, … /progenitor cell population that is resident in the adult heart. …

… been identified in adult hearts, including stem-cell antigen 1-… differentiation of P19CL6 cells
into beating cardiomyocytes and the differentiation of Sca-1 + stem cells into endothelial cells…

… beating cardiomyocytes … the cell surface markers of hematopoietic stem cells [16]. Our and
another group have reported that adult cardiac Sca-1 + cells differentiate into cardiomyocytes …

… To further investigate the differentiation potential of cardiac resident Sca-1 + cells, we … -1–derived
myocardial cells in the adult mouse heart (≈2% to 5% of total cardiomyocytes) than we …

… can give rise to functional cardiomyocytes; however, the … identify single proliferative cells
from the adult heart without progenitor … the Ca 2+ transient in beating cardiomyocytes (Fig. 5C). …