Adult neurogenesis is altered by GABAergic imbalance in models of Alzheimer's disease
AF Schinder, NA Morgenstern - Cell Stem Cell, 2009 - cell.com
AF Schinder, NA Morgenstern
Cell Stem Cell, 2009•cell.com… Therefore, impairment of adult neurogenesis is specific for the apoE4 haplotype and it is
mediated by an imbalance in the network of GABAergic interneurons, rather than a cell-autonomous
effect. Whether abnormal … Carriers of apoE4 are at higher risk for developing Alzheimer's
disease. We have investigated adult neurogenesis in mice with knockout (KO) for apoE or
with knockin (KI) alleles for human apoE3 or apoE4, and we report that neurogenesis is
reduced in both apoE-KO and apoE4-KI mice. In apoE-KO mice, increased BMP signaling …
mediated by an imbalance in the network of GABAergic interneurons, rather than a cell-autonomous
effect. Whether abnormal … Carriers of apoE4 are at higher risk for developing Alzheimer's
disease. We have investigated adult neurogenesis in mice with knockout (KO) for apoE or
with knockin (KI) alleles for human apoE3 or apoE4, and we report that neurogenesis is
reduced in both apoE-KO and apoE4-KI mice. In apoE-KO mice, increased BMP signaling …
Early stages of Alzheimer's disease (AD) affect hippocampal function. In this issue of Cell Stem Cell, Li et al. (2009) and Sun et al. (2009) propose abnormal GABA signaling as a trigger for impaired network plasticity in the AD hippocampus.
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