Advanced glycation end products induce T cell apoptosis: Involvement of oxidative stress, caspase and the mitochondrial pathway
Accumulation of advanced glycation end products (AGEs) is a hallmark in aged people. T
cells play important roles in maintaining homeostasis of immune function. This study
investigated the effects of AGEs-bovine serum albumin (AGEs) in human T cells. Incubation
of Jurkat and several immortalized T cell lines with AGEs resulted in cell death dose-
dependently. AGEs-induced cell death was partially but significantly blocked by neutralizing
antibodies recognizing receptor of AGEs. In addition to detecting DNA nick, simultaneous …
cells play important roles in maintaining homeostasis of immune function. This study
investigated the effects of AGEs-bovine serum albumin (AGEs) in human T cells. Incubation
of Jurkat and several immortalized T cell lines with AGEs resulted in cell death dose-
dependently. AGEs-induced cell death was partially but significantly blocked by neutralizing
antibodies recognizing receptor of AGEs. In addition to detecting DNA nick, simultaneous …
以上显示的是最相近的搜索结果。 查看全部搜索结果