The annual age‐ and sex‐specific patterns of harvest mortality in a Norwegian moose Alces alces population during a period of 17 years for females and 24 years for males were estimated using cohort analysis. In males the harvest mortality increased with age, whereas in females the pattern was U‐shaped with higher harvest mortality of less fecund young (1–3 year) and old (≥ 10 years) age classes, and lower harvest mortality of prime age (4–9 years old) females. In both sexes, the calf harvest mortality was low, although it increased with increasing calf quotas following a change from an indiscriminate to a sex‐ and age‐specific hunting system during the study period. In adult males, the mortality pattern was opposite of what was expected based on the previously reported higher susceptibility to hunting of young than old males, indicating that hunter selectivity for large (old) males affected the pattern. Moreover, the selectivity of the hunters decreased as the hunting pressure increased, suggesting that the hunters became less selective when the mean time available per moose in the quota decreased. Among adult female age groups, the variation in harvest mortality increased with the proportion of calves per female in the population prior to hunting. This was mainly because of relatively higher mortality of post‐prime females, supporting our expectation that hunters avoid shooting females with calves and thus increase the harvest of less fecund age groups during high recruitment years. The observed selectivity led to harvest mortality that differed significantly from patterns of natural mortality, even where the mortality is mainly due to wolves Canis lupus and bears Ursus arctos. This may have consequences for the life history evolution of both male and female moose. The potential ecological, evolutionary and management implications of the results are discussed.