Age-dependent effects of 17β-estradiol on the dynamics of estrogen receptor β (ERβ) protein–protein interactions in the ventral hippocampus
NN Mott, E Pinceti, YS Rao… - Molecular & Cellular …, 2014 - ASBMB
Recent clinical evidence suggests that the neuroprotective and beneficial effects of hormone
therapy may be limited by factors related to age and reproductive status. The patient's age
and length of time without circulating ovarian hormones are likely to be key factors in the
specific neurological outcomes of hormone therapy. However, the mechanisms underlying
age-related changes in hormone efficacy have not been determined. We hypothesized that
there are intrinsic changes in estrogen receptor β (ERβ) function that determine its ability to …
therapy may be limited by factors related to age and reproductive status. The patient's age
and length of time without circulating ovarian hormones are likely to be key factors in the
specific neurological outcomes of hormone therapy. However, the mechanisms underlying
age-related changes in hormone efficacy have not been determined. We hypothesized that
there are intrinsic changes in estrogen receptor β (ERβ) function that determine its ability to …
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