Age-dependent imbalance of the antioxidative system in human satellite cells

S Fulle, S Di Donna, C Puglielli, T Pietrangelo… - Experimental …, 2005 - Elsevier
The mature myofibres of human skeletal muscle are surrounded by a type of adult stem cell,
known as the satellite cell, which lies outside the sarcolemma but within the basal lamina.
These cells remain quiescent until external stimuli trigger their re-entry into the cell cycle. In
humans, ageing is characterised by a progressive loss of muscle mass and strength
(sarcopenia) associated with a decline in functional ability. One of the possible causes of
this decline in muscle performance is a decrease in the antioxidative capacity of skeletal …
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