disease. Although expanded huntingtin is found in virtually every cell type, its toxicity is
limited to neurons of certain areas of the brain, such as cortex and caudate/putamen. In
affected areas of the brain, expanded huntingtin is not found in its intact monomeric form. It is
found instead in the form of N-terminal fragments, oligomers and polymers, all of which
accumulate in the cortex. Whereas the oligomer is mostly soluble, the polymers and the …