The prevalence of periodontal disease seems to be increased in patients with inflammatory bowel disease (IBD). Moreover, the induction of periodontitis seems to result in gut dysbiosis and altered gut epithelial cell barrier function in which one disease might alter the composition of the microbiota and increase the inflammatory response related to the other disease. Such systemic conditions might, also, influence the clinical outcome in case of implant therapy in periodontitis patients as they might affect the soft tissues, the general trabecular bone pattern as well as affect the successful outcomes of osseo-integration. Crohn’s disease is a chronic granulomatous disease process characterized by persistent intestinal inflammation, ulceration, formation of granulomatous lesions and a generalized trans-mural inflammation throughout the intestines. Periodontitis is one of the common oral manifestations of Crohn’s disease which was first described in 1969. The present case report describes a case of aggressive periodontitis in a patient with established Crohn’s disease successfully managed with implant therapy.