Aging-associated miR-217 aggravates atherosclerosis and promotes cardiovascular dysfunction
VG de Yébenes, AM Briones… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: microRNAs are master regulators of gene expression with essential roles in
virtually all biological processes. miR-217 has been associated with aging and cellular
senescence, but its role in vascular disease is not understood. Approach and Results: We
have used an inducible endothelium-specific knock-in mouse model to address the role of
miR-217 in vascular function and atherosclerosis. miR-217 reduced NO production and
promoted endothelial dysfunction, increased blood pressure, and exacerbated …
virtually all biological processes. miR-217 has been associated with aging and cellular
senescence, but its role in vascular disease is not understood. Approach and Results: We
have used an inducible endothelium-specific knock-in mouse model to address the role of
miR-217 in vascular function and atherosclerosis. miR-217 reduced NO production and
promoted endothelial dysfunction, increased blood pressure, and exacerbated …
Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction
VP García-Yébenes Mena, AR Ramiro - 2020 - docta.ucm.es
OBJECTIVE: microRNAs are master regulators of gene expression with essential roles in
virtually all biological processes. miR-217 has been associated with aging and cellular
senescence, but its role in vascular disease is not understood. APPROACH AND RESULTS:
We have used an inducible endothelium-specific knock-in mouse model to address the role
of miR-217 in vascular function and atherosclerosis. miR-217 reduced NO production and
promoted endothelial dysfunction, increased blood pressure, and exacerbated …
virtually all biological processes. miR-217 has been associated with aging and cellular
senescence, but its role in vascular disease is not understood. APPROACH AND RESULTS:
We have used an inducible endothelium-specific knock-in mouse model to address the role
of miR-217 in vascular function and atherosclerosis. miR-217 reduced NO production and
promoted endothelial dysfunction, increased blood pressure, and exacerbated …