Airway structural cells regulate TLR5-mediated mucosal adjuvant activity

L Van Maele, D Fougeron, L Janot… - Mucosal …, 2014 - nature.com
… signaling in airway structural cells drives the flagellin-specific mucosal adjuvant activity on
… , these data suggest that the airway epithelial cells regulate the adjuvant activity of flagellin. …

[PDF][PDF] Airway structural cells regulate TLR5-mediated mucosal adjuvant activity

M Rumbo, S Corvo-Chamaillard, S Boulenouar, S Jeffs… - academia.edu
… swiftly in the airway epithelial compartment. Bronchial and alveolar epithelial cells mostly …
, these data suggest that the airway epithelial cells regulate the adjuvant activity of flagellin. …

Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract

D Fougeron, L Van Maele, P Songhet, D Cayet, D Hot… - Vaccine, 2015 - Elsevier
… However, TLR5-mediated signaling specifically enhanced the maturation of lung dendritic …
Our data suggest that PMNs do not regulate the flagellin's adjuvant activity (as for the adjuvant

Enhanced TLR5-dependent migration and activation of antigen-loaded airway dendritic cells by flagellin

X Li, Y Cao, M Mou, J Li, S Huang… - Journal of Leukocyte …, 2023 - academic.oup.com
… (FBS), the cells were stimulated with SF or the control protein SF△90 … demonstrated that the
mucosal adjuvant activity of SF in … to TLR5-mediated modulation of airway dendritic cells and …

Modes of action for mucosal vaccine adjuvants

T Aoshi - Viral immunology, 2017 - liebertpub.com
… However, the mode of action of flagellin in the airway mucosa (… demonstrated that the mucosal
adjuvant activity of flagellin … of mucosal CD103(+) DCs induces Foxp3(+) regulatory T cells

Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response

Y Cao, E Zhang, J Yang, Y Yang, J Yu… - Journal of leukocyte …, 2017 - academic.oup.com
… When delivered via an in route, airway structural cells—probably respiratory epithelial cells
the regulation of TLR5-mediated mucosal adjuvant activity by respiratory epithelial cells is …

The TLR5 agonist flagellin shapes phenotypical and functional activation of lung mucosal antigen presenting cells in neonatal mice

P Sharma, O Levy, DJ Dowling - Frontiers in immunology, 2020 - frontiersin.org
activity suggests that it may serve as an effective adjuvant for … a more effective mucosal
response to respiratory infections (… an adjuvant during intranasal vaccination, flagellin regulated

The GM-CSF released by airway epithelial cells orchestrates the mucosal adjuvant activity of flagellin

A Vijayan, L Van Maele, D Fougeron… - The Journal of …, 2020 - journals.aai.org
… In this study, we looked at how the airway epithelial cells (AECs) regulate the flagellin-…
the structural AECs but does not have an impact on the alveolar macrophages. TLR5-mediated

The TLR5 agonist flagellin modifies phenotypical and enhances functional activation of lung mucosal antigen presenting cells in neonatal mice

P Sharma, O Levy, DJ Dowling - bioRxiv, 2019 - biorxiv.org
… a more effective mucosal response to respiratory infections (10,… flagellin as a potent mucosal
adjuvant in our early life … be functionally enhanced by TLR5-mediated regulation. Future …

[HTML][HTML] Bronchial epithelial cells release inflammatory markers linked to airway inflammation and remodeling in response to TLR5 ligand flagellin

P Losol, MH Ji, JH Kim, JP Choi, JE Yun, JH Seo… - World Allergy …, 2023 - Elsevier
… In vivo, intranasal administration of flagellin induced mucosal … due to its regulation of airway
fibrosis and airway remodeling … epithelial cells contributed to TLR5-mediated dendritic cell