Angiogenesis contributes to uncontrolled carcinogenesis or cancer cell growth. Tumor or cancer growth can be controlled through inhibition of angiogenesis. One of the natural ingredients that have the potential as a cancer prevention functional food ingredient is black rice. This study aims to study and determine the antiangiogenesis activity of black rice extract (Oryza sativa L. indica) on the Chorioallantoic Membrane (CAM) as an anticancer candidate. The parameters observed in the study were the number of new blood vessels or the response of angiogenesis to CAM after the administration of black rice extract with a concentration of 20, 25, 50, 60 and 75 µg/mL, respectively. The higher the concentration of black rice extract showed a decrease in the number of blood vessels formed. The average number of blood vessels at concentrations of black rice extract 20, 25, 50, 60 and 75 µg/mL were 27.6; 21.0; 3.67; 3.0; 2.0. In the control with 0.9% NaCl solution, the average number of blood vessels was 35.33.