The prevalence of diabetes, hypertension, and cardiovascular disease (CVD) and chronic
kidney disease (CKD) is increasing in concert with obesity. Insulin resistance, metabolic
dyslipidemia, central obesity, albuminuria. and hypertension commonly cluster to comprise
the cardiometabolic syndrome (CMS). Emerging evidence supports a shift in our
understanding of the crucial role of elevated serum aldosterone in promoting insulin
resistance and resistant hypertension. Aldosterone enhances tissue generation of oxygen …