Aldosterone upregulates transient receptor potential melastatin 7 (TRPM7)
WC Valinsky, A Jolly, P Miquel, RM Touyz… - Journal of Biological …, 2016 - ASBMB
Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed Mg 2+-
permeable ion channel fused to a C-terminal α-kinase domain. Recently, aldosterone was
shown to increase intracellular Mg 2+ levels and alter inflammatory signaling in TRPM7-
expressing HEK293 cells. This study was undertaken to assess whether these effects were
related to an aldosterone-mediated increase of TRPM7 current and/or plasma membrane
localization. Using HEK293 cells stably expressing WT-TRPM7, we found that 18-h …
permeable ion channel fused to a C-terminal α-kinase domain. Recently, aldosterone was
shown to increase intracellular Mg 2+ levels and alter inflammatory signaling in TRPM7-
expressing HEK293 cells. This study was undertaken to assess whether these effects were
related to an aldosterone-mediated increase of TRPM7 current and/or plasma membrane
localization. Using HEK293 cells stably expressing WT-TRPM7, we found that 18-h …
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