Alkaline, Endo III and FPG modified comet assay as biomarkers for the detection of oxidative DNA damage in rats with experimentally induced diabetes
Increased production of reactive oxygen species under diabetic condition underlines the
higher oxidatively damaged DNA in different tissues. However, it is practically difficult to
assess the oxidatively damaged DNA in different internal organs. Therefore, the present
study was aimed to evaluate the extent of oxidative stress-induced DNA damage in different
organs with the progression of diabetes. Diabetic and control Sprague Dawley rats were
sacrificed in time-dependent manner and the lung, liver, heart, aorta, kidney, pancreas and …
higher oxidatively damaged DNA in different tissues. However, it is practically difficult to
assess the oxidatively damaged DNA in different internal organs. Therefore, the present
study was aimed to evaluate the extent of oxidative stress-induced DNA damage in different
organs with the progression of diabetes. Diabetic and control Sprague Dawley rats were
sacrificed in time-dependent manner and the lung, liver, heart, aorta, kidney, pancreas and …
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