Allele-allele interaction within the F13A1 gene: a risk factor for ischaemic heart disease in Spanish population
R Carreras-Torres, G Athanasiadis… - Thrombosis …, 2010 - thrombosisresearch.com
Plasma coagulation factor XIII (FXIII) is a pro-transglutaminase essential for haemostasis
which, after being activated by thrombin and Ca2+, plays an important role in the final stages
of blood coagulation and in the regulation of fibrinolysis. Plasma FXIII consists of two A
subunits and two B subunits (carrier molecule), encoded by genes located on chromosomes
6p25-p24 and 1q31-q32. 1, respectively. Activated FXIII cross-links covalently adjacent fibrin
monomers and stabilizes the structure of blood clot [2]. Genetic variation in the sequence of …
which, after being activated by thrombin and Ca2+, plays an important role in the final stages
of blood coagulation and in the regulation of fibrinolysis. Plasma FXIII consists of two A
subunits and two B subunits (carrier molecule), encoded by genes located on chromosomes
6p25-p24 and 1q31-q32. 1, respectively. Activated FXIII cross-links covalently adjacent fibrin
monomers and stabilizes the structure of blood clot [2]. Genetic variation in the sequence of …
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