Altered miRNA signature of developing germ-cells in infertile patients relates to the severity of spermatogenic failure and persists in spermatozoa
X Muñoz, A Mata, L Bassas, S Larriba - Scientific reports, 2015 - nature.com
The aim of this study was to assess the cellular miRNA expression behaviour in testes with
spermatogenic failure (SpF). We performed a high-throughput screen of 623 mature miRNAs
by a quantitative RT-qPCR-based approach in histologically well-defined testicular samples
with spermatogenic disruption at different germ-cell stages, which revealed altered patterns
of miRNA expression. We focussed on the differentially expressed miRNAs whose
expression correlated with the number of testicular mature germ-cells and described the …
spermatogenic failure (SpF). We performed a high-throughput screen of 623 mature miRNAs
by a quantitative RT-qPCR-based approach in histologically well-defined testicular samples
with spermatogenic disruption at different germ-cell stages, which revealed altered patterns
of miRNA expression. We focussed on the differentially expressed miRNAs whose
expression correlated with the number of testicular mature germ-cells and described the …
Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa
X Muñoz Miralles, A Mata, L Bassas… - Scientific Reports, 2015 …, 2015 - diposit.ub.edu
The aim of this study was to assess the cellular miRNA expression behaviour in testes with
spermatogenic failure (SpF). We performed a high-throughput screen of 623 mature miRNAs
by a quantitative RT-qPCR-based approach in histologically well-defined testicular samples
with spermatogenic disruption at different germ-cell stages, which revealed altered patterns
of miRNA expression. We focussed on the differentially expressed miRNAs whose
expression correlated with the number of testicular mature germ-cells and described the …
spermatogenic failure (SpF). We performed a high-throughput screen of 623 mature miRNAs
by a quantitative RT-qPCR-based approach in histologically well-defined testicular samples
with spermatogenic disruption at different germ-cell stages, which revealed altered patterns
of miRNA expression. We focussed on the differentially expressed miRNAs whose
expression correlated with the number of testicular mature germ-cells and described the …
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