Altered microRNA expression profile is linked to T-cell exhaustion-related pathways in pediatric patients with acute lymphoblastic leukemia
Background Although the phenotype and functions of exhausted T cells in several cancers
have been identified, the involved molecular mechanisms remain to be further elucidated. In
this regard, we have recently reported that the immunoregulatory cells, including myeloid-
derived suppressor cells (MDSCs) and regulatory T cells (T regs), share common
dysregulated miRNAs that target specific immunosuppressive pathways in patients with in
acute lymphoblastic leukemia (ALL). Aim: In this study, we aimed to further explore whether …
have been identified, the involved molecular mechanisms remain to be further elucidated. In
this regard, we have recently reported that the immunoregulatory cells, including myeloid-
derived suppressor cells (MDSCs) and regulatory T cells (T regs), share common
dysregulated miRNAs that target specific immunosuppressive pathways in patients with in
acute lymphoblastic leukemia (ALL). Aim: In this study, we aimed to further explore whether …
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