Thioredoxin and glutathione systems are the major thiol-dependent redox systems in animal
cells. They transfer via the reversible oxidoreduction of thiols the reducing equivalents of
NADPH to numerous substrates and substrate reductases and constitute major defenses
against oxidative stress. In this study, we cloned from the helminth parasite Echinococcus
granulosus two trans-spliced mRNA variants that encode thioredoxin glutathione reductases
(TGR). These variants code for mitochondrial and cytosolic selenocysteine-containing …