Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice
Exposure to ambient particulate matter (PM) is a risk factor for cardiovascular diseases. The
redox-active ultrafine particles (UFPs) promote vascular oxidative stress and inflammatory
responses. We hypothesized that UFPs modulated lipid metabolism and anti-oxidant
capacity of high density lipoprotein (HDL) with an implication in atherosclerotic lesion size.
Fat-fed low density lipoprotein receptor-null (LDLR−/−) mice were exposed to filtered air (FA)
or UFPs for 10 weeks with or without administering an apolipoprotein AI mimetic peptide …
redox-active ultrafine particles (UFPs) promote vascular oxidative stress and inflammatory
responses. We hypothesized that UFPs modulated lipid metabolism and anti-oxidant
capacity of high density lipoprotein (HDL) with an implication in atherosclerotic lesion size.
Fat-fed low density lipoprotein receptor-null (LDLR−/−) mice were exposed to filtered air (FA)
or UFPs for 10 weeks with or without administering an apolipoprotein AI mimetic peptide …
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